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目的:观察早期治疗极低出生体重儿脑室周围白质软化的效果。方法:将脑室周围白质软化的45例极低出生体重儿分为治疗组21例及对照组24例。在常规治疗的基础上,治疗组另给予单唾液酸四已糖神经节苷脂钠注射液(GM-1)治疗,动态观察两组头颅B超的变化及神经行为(NBNA)评分。结果:GM-1治疗组头颅B超的变化及NBNA评分明显优于对照组,有统计学差异。结论:早期治疗可以减轻极低出生体重儿脑室周围白质软化及持续性病变的发生,改善预后。
Objective: To observe the effect of early treatment of periventricular leukomalacia in very low birth weight infants. Methods: Forty-five cases of very low birth weight infants with periventricular leukomalacia were divided into treatment group (21 cases) and control group (24 cases). On the basis of conventional treatment, the treatment group was treated with monosialotetraosyl ganglioside sodium injection (GM-1), and the changes of cranial ultrasound and neurological behavior (NBNA) were observed. Results: The changes of cranial ultrasound and NBNA score in GM-1 treatment group were significantly better than those in control group, with statistical difference. Conclusion: Early treatment can reduce the incidence of periventricular leukomalacia and persistent lesions in very low birth weight children and improve the prognosis.