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目的 观察低剂量甲基强的松龙联合胃复安、苯海拉明预防顺铂所致呕吐反应的止吐疗效和毒副反应。方法 采用随机、自身前后对照的方法 ,将 45例接受顺铂联合化疗的初治恶性肿瘤患者 ,分为AB和BA组 ,AB组第 1周期用A方案 (甲基强的松龙联合方案 ) ,第 2周期用B方案 (蒽丹西酮单药方案 )。BA组反之。前后2周期化疗方案完全相同。比较两种方案的止吐疗效及毒副反应。结果 A、B方案均有较好的止吐疗效 ,在呕吐控制率、平均呕吐次数、恶心控制率及食欲影响情况方面 ,两方案间比较差异无显著意义 (P >0 0 5 ) ,但A方案食欲恢复时间明显短于B方案 (P <0 0 5 )。此外 ,两方案在不同年龄组间比较无差异 (P >0 0 5 )。两方案毒副反应均小 ,可耐受。结论 甲基强的松龙、胃复安、苯海拉明联合方案安全有效 ,其价格优势突出 ,可于临床应用。
Objective To observe the effect of low dose methylprednisolone combined with metoclopramide and diphenhydramine in preventing antiemetic efficacy and toxicity of cisplatin-induced vomiting. Methods 45 cases of newly diagnosed malignant tumor treated with cisplatin combined with chemotherapy were randomly divided into AB and BA groups. The first cycle of AB group was treated with A regimen (methylprednisolone combination regimen) , The second cycle with the B program (anthracycline single drug program). In contrast, BA group. The two cycles of chemotherapy were exactly the same. Compare the two kinds of antiemetic efficacy and side effects. Results Both A and B regimens had better antiemetic efficacy. There was no significant difference between the two regimens in the control of vomiting, vomiting, nausea control and appetite (P> 0.05), but A The duration of appetite recovery was significantly shorter than that of the B regimen (P <0 05). In addition, there was no difference between the two schemes in different age groups (P> 0.05). Two side effects are small, tolerable. Conclusion Methylprednisolone, metoclopramide and diphenhydramine combination are safe and effective, and their price advantage is prominent, which can be applied in clinic.