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目的:探讨振腹法对2型糖尿病(T2DM)模型大鼠胰岛素抵抗程度的影响。方法:用高糖高脂联合小剂量链脲佐菌素(30 mg/kg)建立实验型T2DM大鼠模型,根据振动频率分为低频治疗组(300次/min)和高频治疗组(600次/min),进行6周振腹干预,测定空腹血糖(FBG)、血清胰岛素水平(INS)、胰岛素敏感指数(ISI)、餐后2 h血糖(2h PG)及游离脂肪酸(FFA)水平,计算ISI并与对照组和模型组进行比较。结果:振腹干预6周后高频治疗组、低频治疗组与模型组比较,ISI值上升,FBG、INS、2h PG、FFA水平明显降低,差异有统计学意义(P<0.05);低频治疗组与高频治疗组比较,各项指标差异均无统计学意义(P>0.05);高频对照组、低频对照组与对照组比较,各项指标差异无统计学意义(P>0.05)。结论:振腹法可降低T2DM大鼠血清INS含量、提高ISI水平,改善胰岛素抵抗程度,其机制可能与降低大鼠血清FFA含量有关;对正常大鼠无此效应,认为振腹效应的产生与机体状态有关。
Objective: To investigate the effect of vibrating belly on insulin resistance in type 2 diabetes mellitus (T2DM) rats. Methods: Experimental T2DM rat model was established by high glucose and high fat combined with low dose of streptozotocin (30 mg / kg). The model was divided into low frequency treatment group (300 times / min) and high frequency treatment group (FBG), serum insulin (INS), insulin sensitivity index (ISI), 2 h postprandial blood glucose (2h PG) and free fatty acid (FFA) ISI was calculated and compared with control and model groups. Results: Compared with the model group, the ISI value of FBG, INS, 2h PG and FFA were significantly decreased in high-frequency treatment group and low-frequency treatment group after 6 weeks of vibration-sensitive intervention (P <0.05) There was no significant difference in each index between high frequency group and high frequency group (P> 0.05). There was no significant difference between high frequency control group and low frequency control group and control group (P> 0.05). CONCLUSION: Vibrating abdomen method can reduce the level of serum INS, increase the level of ISI and the degree of insulin resistance in T2DM rats. The mechanism may be related to the decrease of serum FFA level in rats. In normal rats, there is no such effect. Body state related.