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第10号染色体同源缺失性磷酸酶-张力蛋白基因(phosphataseandtensinhomologdeletedonchromosometen,PTEN)在多种肿瘤中存在突变。PTEN基因产物具有蛋白磷酸酶活性和脂质磷酸酶活性,其C端可调节PTEN在膜上的靶向定位。结合到质膜上的PTEN通过催化磷脂酰肌醇3,4,5-三磷酸(phosphatidylinositol3,4,5-triphosphate,PIP3)的降解来调节细胞内PIP3水平,对PKB/Akt途径进行负调控。在细胞内,PTEN与许多细胞表面受体相互作用,对一些受体介导的信号转导途径进行负调节,从而调控细胞的增殖、迁移和侵袭。PTEN也通过与p53蛋白结合,调节基因转录,进而对细胞生长或细胞凋亡进行调控。
The chromosome 10 homologous deletion phosphatase - tensin gene (phosphataseandtensinhomologdeletedonchromosometen, PTEN) in a variety of tumors there is a mutation. PTEN gene product has protein phosphatase activity and lipid phosphatase activity, and its C-terminal can regulate PTEN targeting on the membrane. PTEN, which binds to the plasma membrane, regulates intracellular PIP3 levels by catalyzing the degradation of phosphatidylinositol 3,4,5-triphosphate (PIP3), negatively regulating the PKB / Akt pathway. Within the cell, PTEN interacts with many cell surface receptors and negatively regulates some of the receptor-mediated signal transduction pathways to regulate cell proliferation, migration and invasion. PTEN also regulates gene transcription by binding to p53 protein, which in turn regulates cell growth or apoptosis.