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目的:评价中西医结合法治疗颈动脉粥样硬化的临床疗效。方法:纳入以颈动脉粥样硬化为研究对象的临床随机对照试验,用Revman 5.2软件进行Meta分析。结果:所纳入的9篇研究,质量普遍不高,经Meta分析显示,采用中西医结合法治疗颈动脉粥样硬化患者,血脂[包括血清胆固醇(TC)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)]的总体疗效优于单用西药治疗。其中TC疗效评价,汇总SMD 0.96[(95%CI(1.13~0.79)],差异有统计学意义(P<0.00001);HDL-C疗效评价,汇总SMD 0.25[(95%CI(0.08~0.42)],差异有统计学意义(P<0.00001),LDL-C疗效评价,汇总SMD 0.81[(95%CI(1.22~0.40)],差异有统计学意义(P=0.00001)。结论:采用中西医结合治疗颈动脉粥样硬化患者,血脂的总体疗效与单用西药治疗比较有可能更有效,但尚需更多高质量研究以增加证据的力度。
Objective: To evaluate the clinical efficacy of combining traditional Chinese and western medicine in the treatment of carotid atherosclerosis. Methods: A randomized, controlled clinical trial of carotid atherosclerosis was included. Meta-analysis was performed using Revman 5.2 software. Results: The quality of the 9 studies included in the study was generally not high. Meta-analysis showed that the levels of serum lipids [including serum cholesterol (TC), high density lipoprotein (HDL-C) , Low density lipoprotein (LDL-C)] than the overall efficacy of Western medicine alone. The efficacy of TC was evaluated by summarizing SMD 0.96 [95% CI (1.13-0.79)], the difference was statistically significant (P <0.00001) ], The difference was statistically significant (P <0.00001), LDL-C efficacy evaluation, summary SMD 0.81 [(95% CI 1.22 ~ 0.40)], the difference was statistically significant (P = 0.00001) .Conclusion: Combined treatment of patients with carotid atherosclerosis, the overall efficacy of blood lipids and Western medicine alone is more likely to be more effective, but still need more high-quality research to increase the intensity of evidence.