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矽肺是一种由游离的二氧化硅(SiO2)所导致的以肺组织弥漫性纤维化为主要病理改变的疾病,病变不仅累及肺间质,还可累及肺泡上皮细胞和血管,其主要病理改变是肺泡上皮的损伤、大量成纤维细胞灶的形成、细胞外基质的超负荷沉积,最终结果是肺组织结构异常重塑[1]。纤维化进程涉及到各种细胞、细胞因子、细胞外基质(ECM)等因素的相互作用,是多因素、多环节一起参与的过程,肺泡巨噬细胞的细胞
Silicosis is a disease caused by free silica (SiO2), which is the main pathological change of diffuse fibrosis in lung tissue. The lesions not only involve the interstitial lung, but also affect the alveolar epithelial cells and blood vessels. The main pathological changes Is alveolar epithelial damage, the formation of a large number of fibroblastic foci, extracellular matrix overload deposition, the end result is an abnormal lung tissue remodeling [1]. Fibrosis process involves a variety of cells, cytokines, extracellular matrix (ECM) and other factors, is a multi-factor, multi-link together the process of alveolar macrophages cells