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目的探讨舒血宁联合多巴丝肼片治疗早期帕金森病患者的临床效果。方法选取营口经济技术开发区中心医院于2015年1月至2016年12月收治的50例早期帕金森病患者作为研究对象,随机分为对照组与研究组,各25例。对照组患者给予多巴丝肼片,研究组患者在对照组基础上采用舒血宁治疗。比较两组患者治疗前后统一帕金森病评分量表(UPDRS)评分、临床治疗效果、不良反应发生情况。结果治疗后,研究组患者精神、情绪与行为、日常生活能力与运动检查评分均明显低于对照组,差异均有统计学意义(均P<0.05);研究组患者治疗的总有效率明显高于对照组,差异有统计学意义(P<0.05)。结论在治疗早期帕金森病时使用舒血宁联合多巴丝肼片临床效果显著,且安全性较高。
Objective To investigate the clinical effects of Shuxuening combined with Doxapine in the treatment of patients with early Parkinson’s disease. Methods Fifty patients with early Parkinson disease admitted from January 2015 to December 2016 in Central Hospital of Yingkou Economic and Technological Development Zone were randomly divided into control group and study group, with 25 cases in each group. Patients in the control group were treated with domperidone, while those in the study group were treated with Shuxuening on the basis of the control group. The difference of UPDRS score, clinical treatment effect and adverse reaction between the two groups before and after treatment were compared. Results After treatment, the scores of mental, emotional and behavioral, daily living and motor examination in the study group were significantly lower than those in the control group (all P <0.05). The total effective rate of the study group was significantly higher In the control group, the difference was statistically significant (P <0.05). Conclusions Shuxuening combined with Doxoplasmin in the treatment of early Parkinson’s disease has significant clinical effect and high safety.