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目的：观察乙肝３ 号冲剂治疗慢性乙型肝炎的疗效。方法：选择慢性乙肝中重度患者１２０ 例，随机分成两组，治疗组口服乙肝３ 号冲剂，对照组皮下注射α干扰素３００ 万Ｕ，观察治疗后肝功能、ＨＢＶ－Ｍ 和肝纤维化指标的变化。结果：经治疗后谷丙转氨酶、γ球蛋白、血清胆红素、血清透明质酸和ＩＶ 胶原均明显降低，与对照组比较，有显著性差异（Ｐ＜ ０．０５，＜ ０．０１）；ＨＢｅＡｇ 和ＨＢＶ－ＤＮＡ 的阴转率分别为４０．０％ 和４３．３％ ，低于对照组４８．３％ 和５３．３％ ，但无统计学差异（Ｐ＞ ０．０５）。结论：乙肝３ 号冲剂是治疗慢性乙型肝炎的较好药物。
Objective: To observe the curative effect of Hepatitis B 3 granules on chronic hepatitis B Methods: One hundred and twenty patients with moderate-severe chronic hepatitis B were selected and randomly divided into two groups. The treatment group was given HB 3 granule orally and the control group was injected subcutaneously with IFN-α 3 million U. The liver function, HBV-M and liver fibrosis indexes Variety. Results: After treatment, alanine aminotransferase, γ - globulin, serum bilirubin, serum hyaluronic acid and collagen IV were significantly decreased compared with the control group, there was a significant difference (P <0.05, <0.01) ; The negative conversion rates of HBeAg and HBV-DNA were 40.0% and 43.3% respectively, which were lower than those of the control group (48.3% and 53.3%), but no significant difference (P> 0.05). Conclusion: Hepatitis B 3 granules is a better drug for chronic hepatitis B treatment.