精子发生包括精原细胞的增殖分化、精母细胞减数分裂及圆形精子细胞形态学改变。每一个过程都受到各种转录因子、基因或信号通路的高度调控。近年来,由于深度测序技术的进步,使我们对转录复杂性的认识从以mRNA为中心跳跃到一个高度保守的非翻译转录组——非编码RNA(ncRNA)。包括小分子ncRNA(miRNA、rRNA、piRNA等)及lncRNA,关于小分子RNA在精子发生中的作用已经有很深入 Spermatogenesis includes proliferation and differentiation of spermatogonia, meiosis of spermatocytes and morphological changes of round spermatids. Each process is highly regulated by various transcription factors, genes or signaling pathways. In recent years, advances in deep sequencing have led us to leapfrog our understanding of transcriptional complexity from mRNA-centered jumping to a highly conserved untranslated transcriptome called non-coding RNA (ncRNA). Including small molecule ncRNA (miRNA, rRNA, piRNA, etc.) and lncRNA, on the role of small RNA in spermatogenesis has been very deep