该研究对一次麻疹暴发流行进行了分析,以探讨已接受全程预防接种的人群其发病后伴有皮疹的危险因素和复种麻疹疫苗后的效益。方法对1989年2月1日～3月30日来自美国德克萨斯州Harris郡的2所中等专业学校(6～8年级)和一所中学(9～12年级)的学生进行了调查。在已确定这所学校发生过一次麻疹暴发之后,为三所学校的学生复种麻疹-流行性腮腺炎-风疹疫苗,同时填写了问卷调查并取1份血样。血清的检测采用酶联免疫分析法(EIA),EIA阴性的血标本作中和试验检测中和抗体(NEUT)。然后行统计学处理。结果在麻疹暴发期,三所学校发生77例患者,71例在中学(发病率3.2%),6例在二所中专学校(发病率 The study analyzed the prevalence of a measles outbreak to examine the risk factors associated with a rash and the benefits of a multiple-dose measles vaccine in those already vaccinated. METHODS: Students from 2 secondary vocational schools (grades 6-8) and one secondary school (grades 9-12) from Harris County, Texas, USA, from February 1 to March 30, 1989, were surveyed. After having identified an outbreak of measles in the school, the measles-mumps-rubella vaccine was given to three school pupils, along with a questionnaire and a blood sample. Serum was detected by enzyme-linked immunosorbent assay (EIA), EIA-negative blood samples for neutralization test neutralizing antibody (NEUT). Then line statistics. Results In the outbreak of measles, 77 patients were in three schools, 71 were in secondary school (the incidence was 3.2%) and 6 were in two secondary schools (incidence