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[目的]观察舒肝解郁胶囊联合四联疗法(埃索美拉唑、阿莫西林、胶体果胶铋、克拉霉素)对幽门螺杆菌(Hp)阳性胃溃疡的临床疗效与安全性。[方法]89例Hp阳性胃溃疡患者,随机分为观察组(45例)、对照组(44例)。对照组采用四联疗法治疗2周,然后予以埃索美拉唑抑酸治疗4周;观察组在对照组基础上从第1~6周加用舒肝解郁胶囊2片、2次/d进行治疗。观察2组患者胃泌素浓度(GAS)、胃动素浓度(MTL)、临床症状评分、疗效、Hp根除率及用药不良反应。[结果]经过6周治疗,2组患者GAS浓度、MTL浓度及临床症状评分较治疗前均有显著改善;观察组患者GAS浓度、MTL浓度及临床症状评分均显著低于对照组(P<0.05);观察组治疗总有效率为95.56%、Hp根除率为93.33%,显著高于对照组(P<0.05);观察组不良反应发生率显著低于对照组(P<0.05)。[结论]舒肝解郁胶囊联合四联疗法治疗Hp阳性溃疡相对于四联疗法可更有效缓解患者临床症状、提高溃疡愈合率和Hp根除率,不良反应相对较少,值得推广。
[Objective] To observe the clinical efficacy and safety of Shugan Jieyu capsules combined with quadruple therapy (esomeprazole, amoxicillin, colloidal bismuth pectin, clarithromycin) on Helicobacter pylori (Hp) -positive gastric ulcer. [Method] 89 patients with Hp positive gastric ulcer were randomly divided into observation group (45 cases) and control group (44 cases). The control group was treated with quadruple therapy for 2 weeks, and then treated with esomeprazole for 4 weeks. On the basis of the control group, the observation group was treated with Shugan Jieyu capsule 2 to 2 times a day For treatment. Gastrin concentration (GAS), motilin concentration (MTL), clinical symptom score, curative effect, Hp eradication rate and adverse drug reactions were observed in two groups. [Results] After 6 weeks of treatment, GAS concentration, MTL concentration and clinical symptom scores in both groups were significantly improved compared with those before treatment; GAS concentration, MTL concentration and clinical symptom scores in the observation group were significantly lower than those in the control group (P <0.05 ). The total effective rate of observation group was 95.56% and the eradication rate of Hp was 93.33%, which was significantly higher than that of control group (P <0.05). The incidence of adverse reactions in observation group was significantly lower than that of control group (P <0.05). [Conclusion] Shugan Jieyu capsule combined with quadruple therapy can effectively alleviate the clinical symptoms of patients with Hp-positive ulcer and improve the ulcer healing rate and Hp eradication rate. Compared with quadruple therapy, Hp-positive ulcer is relatively worthy of promotion.