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目的:运用雷泰计划系统(Linatech TPS)验证瓦里安Eclipse调强放疗(Eclipse IMRT)计划剂量的准确性。方法:随机选取鼻咽癌患者6例,男、女各3例;乳腺癌术后患者8例,患者全为女性,左侧5例,右侧3例。鼻咽癌动态调强计划采用9野均分照射,原发灶(PGTVnx)处方剂量为7392 c Gy;乳腺癌动态调强计划采用5~7野照射,处方剂量50 Gy。将计划分别以各向异性分析算法(Anisotropy Analysis Algorithm,AAA)和光子剂量算法(Acuros External Beam Algorithm,Acuros XB)进行剂量计算,计算完成后将该计划以DICOM格式导入Linatech TPS中进行剂量计划方法(Dose Planning Methods,DPM)蒙特卡罗算法计算。以处方剂量包绕95%靶区体积为计划接受标准,分别比较3种算法得到的靶区的最大剂量、平均剂量和相对差异。结果:AAA和DPM相对于Acuros XB在乳腺癌的差异较小,危及器官最大差异分别为对侧肺和对侧乳腺,最大差值分别为5.9%和9.3%;计划靶区(PTV)的最大差异分别为4.9%和4.6%。而在鼻咽癌中的差异相对较大,AAA和DPM相对于Acuros XB的危及器官最大差异都为左晶体,最大差值分别为15.4%和35.5%;靶区的最大差异分别为PTV2和PGTVnx,最大差值分别为4.2%和11.1%。差异具有统计学意义。结论:3种算法在鼻咽癌中的剂量差异相对较大,在乳腺癌中的剂量差异相对较小,且体积越小,差异越大。
Objective: To validate the planned dose of Varian Eclipse IMRT using Linatech TPS. Methods: Six patients with nasopharyngeal carcinoma were selected randomly, 3 males and 3 females, 8 postoperative patients with breast cancer, all of whom were female. There were 5 cases on the left and 3 cases on the right. The dynamic tonometry of nasopharyngeal carcinoma (NPC) was planned to be performed using 9 wild-type irradiation with a dose of 7392 c Gy for primary tumor (PGTVnx) and 5 Gy for 50% of breast cancer. The plan was dose calculated with Anisotropy Analysis Algorithm (AAA) and Acuros External Beam Algorithm (Acuros XB) respectively. After the calculation was completed, the plan was imported into Linatech TPS in DICOM format for dose planning (Dose Planning Methods, DPM) Monte Carlo algorithm. The target dose of 95% of the volume of the target area was taken as the standard accepted by the protocol. The maximum dose, the average dose and the relative difference of the three target areas were compared. Results: The differences between AAA and DPM in breast cancer were smaller than those in Acuros XB. The maximum difference in the organs at risk was 5.9% vs 9.3% for the contralateral and the contralateral breasts respectively. The maximum PTV The differences were 4.9% and 4.6% respectively. While the differences in NPC were relatively large. The biggest difference in the organs at risk of AAA and DPM relative to Acuros XB were left crystals with the maximum difference of 15.4% and 35.5%, respectively. The maximum differences of target area were PTV2 and PGTVnx , The biggest difference is respectively 4.2% and 11.1%. The difference was statistically significant. CONCLUSION: The three algorithms have relatively large dose differences in NPC and relatively small dose differences in breast cancer. The smaller the volume, the greater the difference.