文章简介间充质干细胞(MSCs)是脂肪细胞和成骨细胞的共同源泉,其向脂肪细胞和成骨细胞分化的状态失衡与多种代谢疾病如肥胖、骨质疏松和骨硬化症等密切相关。本研究通过体内体外实验发现,蛋白酪氨酸磷酸酶SHP1作为细胞内信号传导的关键分子,直接调控MSCs成脂成骨分化。进一步研究发现,SHP1对MSCs成骨 Article Outline Mesenchymal stem cells (MSCs) are a common source of adipocytes and osteoblasts. The imbalance of adipocytes and osteoblasts differentiation is closely related to many metabolic diseases such as obesity, osteoporosis and osteosclerosis . In this study, in vitro and in vivo experiments found that protein tyrosine phosphatase SHP1 as a key intracellular signaling molecules, MSCs directly into osteogenic differentiation. Further study found that SHP1 osteogenic MSCs