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目的 :观察硝苯地平缓释片的降压效果及对肝、肾功能等的影响。方法 :5 0例高血压病人于用药前进行2 4h动态血压监测 ,并检查肝、肾功能、血糖、电解质、血脂、心电图等 ,然后给予硝苯地平缓释片 2 0mg ,PO ,bid ,× 4周。 4周后再行动态血压监测并复查相应检验项目 ,比较治疗前后各项指标的变化。结果 :Ⅰ、Ⅱ期高血压病人呈白天高、夜间低的变化规律 ,Ⅲ期病人舒张压失去昼夜变化规律 ,硝苯地平缓释片对昼夜血压均显示良好的降压效果 (P <0 .0 1)。治疗前后肝、肾功能、血糖、电解质、血脂、血常规、心电图均无明显变化 (P>0 .0 5 )。结论 :硝苯地平缓释片具有良好的降压效果 ,对肝肾功能、血糖、血脂、电解质等无不良影响。
Objective: To observe the antihypertensive effects of nifedipine sustained-release tablets and its effects on liver and kidney function. Methods: Fifty patients with hypertension underwent 24 hours ambulatory blood pressure monitoring before treatment and liver, kidney function, blood glucose, electrolytes, blood lipids, electrocardiogram and so on. Then they were given nifedipine sustained-release tablets 20mg, PO, bid, 4 weeks. Four weeks later, ambulatory blood pressure monitoring and review of the corresponding test items, compare the changes in the indicators before and after treatment. Results: The changes of high and low nighttime in patients with stage Ⅰ and Ⅱ hypertension were not obvious. The changes of diurnal and diastolic blood pressure in stage Ⅲ patients were lost. Nifedipine sustained release tablets showed good antihypertensive effect on diurnal blood pressure (P <0. 0 1). Before and after treatment, liver, kidney function, blood glucose, electrolytes, blood lipids, blood and electrocardiogram showed no significant changes (P> 0.05). Conclusion: Nifedipine sustained-release tablets have a good antihypertensive effect on liver and kidney function, blood glucose, blood lipids, electrolytes and other adverse effects.