老年急性心肌梗塞内分泌变化特点及其对糖代谢的影响

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连续测定了29例急性心肌梗塞(AMI)患者2周内血浆儿茶酚胺(CA)、游离三碘甲状腺原氨酸(FT_3)、β内啡肽(β-EP)、生长激素(GH)、胰岛素(INS)、胰高血糖素(GLu)和血糖(G)的变化,其中老年前组16例,老年组13例,并以22例健康成年人作对照。结果:AMI发病后24h内血浆去甲肾上腺素(NE)、肾上腺素(E)、β-EP、GH、GLu、G均明显高于对照组,FT_3及老年前组的INS水平明显低于对照组;相关性分析显示,G与NE、E、β-EP、GH、GLu呈明显的正相关,与FT_3和INS呈明显的负相关。老年组与老年前组的不同点在于:对应激刺激反应迟钝,激素曲线波动性小,恢复正常水平所需的时间长,并且在应激状态下显示出明显的胰岛素抗性。研究提示:老年AMI患者内分泌改变对糖代谢的影响是复杂的,多因素的,随时相的改变而改变。 The levels of plasma catecholamine (CA), free triiodothyronine (FT_3), beta-endorphin (β-EP), growth hormone (GH), insulin ( INS), glucagon (GLu) and blood glucose (G). Among them, 16 were in the pre-aging group and 13 were in the aging group, and 22 healthy adults were used as controls. Results: Plasma norepinephrine (NE), epinephrine (E), β-EP, GH, GLu and G were all significantly higher than those of the control group within 24 hours after onset of AMI. The levels of INS in FT 3 and pre-aging group were significantly lower than those in control The correlation analysis showed that there was a significant positive correlation between G and NE, E, β-EP, GH, GLu, and negatively correlated with FT 3 and INS. The difference between the elderly group and the older group was that they were slow to respond to stress stimuli, had small fluctuations in the hormone profile, required long time to return to normal levels, and showed marked insulin resistance under stress. Research suggests that: elderly patients with AMI endocrine changes on the impact of glucose metabolism is complex, multi-factor, with the change of the phase change.
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