论文部分内容阅读
目的:探讨喉咽鳞癌组织中细胞角蛋白4(CK4)的表达及其临床意义。方法:应用免疫组织化学方法检测60例喉咽鳞癌患者的癌旁正常组织和癌组织标本中CK4的表达。结果:CK4在癌旁正常组织中表达强阳性,在喉咽鳞癌组织中表达下降,其差异有统计学意义(x2=73.594,P<0.05)。与高分化鳞癌相比,CK4在中分化和低分化鳞癌组织中表达均出现明显下降,其差异有统计学意义(F=57.082,P<0.05)。结论:CK4在喉咽鳞癌组织中的低表达对喉咽鳞癌的诊断有一定的临床意义,并有望成为喉咽鳞癌恶性程度的生物学标记物。
Objective: To investigate the expression of cytokeratin 4 (CK4) in hypopharyngeal squamous cell carcinoma and its clinical significance. Methods: Immunohistochemistry was used to detect the expression of CK4 in normal tissues and cancerous tissues from 60 patients with hypopharyngeal squamous cell carcinoma. Results: The expression of CK4 was strongly positive in adjacent normal tissues and decreased in squamous cell carcinoma of the hypopharyngeal squamous cell carcinoma (x2 = 73.594, P <0.05). Compared with well-differentiated squamous cell carcinoma, the expression of CK4 in moderately differentiated and poorly differentiated squamous cell carcinoma was significantly decreased (P <0.05). Conclusion: The low expression of CK4 in squamous cell carcinoma of the larynx pharyngeal squamous cell carcinoma of the hypopharyngeal squamous cell carcinoma has a certain clinical significance, and is expected to become a malignant degree of hypopharyngeal squamous cell carcinoma biological markers.