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在体和离体心脏实验表明,钾钙之间和钾钠之间都有相互拮抗作用。临床上对于高血钾引起的心脏中毒可用钙盐与钠盐治疗。但是它们作用的机制不很清楚。Hoffman等与李少如等曾先后在狗与兔身上作过一些观察。本文观察高钾、高钙对黄鳝心肌细胞跨膜电位的影响,试图从不同动物细胞水平的电活动探讨共机制。 实验共用黄鳝(100—125克)16条,毁损脑脊髓仰卧固定于术极上,暴露心脏,分别结扎左右前膣静脉和左右腔静脉,然后在右后腔静脉插入直径3mm左右塑料管灌注
In vivo and in vitro cardiac experiments show that there is mutual antagonism between potassium and potassium and between sodium and potassium. Cardiac poisoning caused by hyperkalemia clinically available calcium and sodium treatment. But their mechanism of action is not clear. Hoffman et al. And Li Shaotu et al. Have made some observations on dogs and rabbits successively. This article observed the effects of high potassium and high calcium on the transmembrane potential of eel myocardial cells in an attempt to explore the mechanism of co-mechanism from the electrical activity at different animal cell levels. Experiments shared eel (100-125 grams) 16, destroying the spinal cord supine fixed in the surgery pole, exposing the heart, were ligated left and right anterior veins and left and right vena cava, and then into the right posterior vena cava about 3mm in diameter plastic tube perfusion