选用年轻人冠状动脉材料，免疫组织化学方法，观察了弥漫性内膜增厚、脂纹、动脉粥样硬化斑块中平滑肌细胞的免疫表型变化，并将这些变化同巨噬细胞进行了联系。结果表明，凡是有巨噬细胞浸润之处，不管何种病变，该处的平滑肌细胞便失去了相应抗体的反应性，但仍能被抗间叶细胞抗体所标记，提示平滑肌细胞已经发生表型转变。这一现象说明巨噬细胞在平滑肌细胞表型转变过程中起重要作用，有助于人们对动脉粥样硬化病变、冠脉成形术后再狭窄病变发生过程的认识。 Selection of young coronary material, immunohistochemical methods to observe diffuse intima thickening, lipid pattern, atherosclerotic plaque smooth muscle cell immunophenotypic changes, and these changes were linked with macrophages . The results showed that, where macrophage infiltration, no matter what kind of lesions, where the smooth muscle cells will lose the corresponding antibody reactivity, but still can be labeled anti-mesenchymal cells, suggesting that smooth muscle cells have phenotype change. This phenomenon indicates that macrophages play an important role in the process of smooth muscle cell phenotype transformation and contribute to the understanding of the pathogenesis of atherosclerotic lesions and restenosis after coronary angioplasty.