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目的:观察热毒宁注射液治疗小儿急性细菌性肠炎的临床疗效及安全性。方法:将64例急性细菌性肠炎患儿按随机数字法分为治疗组和对照组各32例,对照组予以头孢克肟抗感染及对症支持治疗;治疗组在对照组治疗基础上加用热毒宁注射液治疗,比较两组患儿治疗后的临床疗效、大便常规检查、临床症状消失时间及药物不良反应发生情况。结果:治疗组总有效率为90.6%,明显高于对照组的68.8%(P<0.05)。治疗组治疗第3 d、第5 d大便常规转阴率分别为65.6%、96.9%,对照组分别为56.3%、75.0%,两组患儿治疗第3 d大便常规转阴率无明显差异(P>0.05),但治疗组治疗第5 d大便常规转阴率明显高于对照组(P<0.05)。治疗组脱水纠正时间、大便恢复正常时间分别为(2.70±0.68)d、(3.02±0.53)d,对照组为(4.11±1.02)d、(5.08±1.08)d。治疗组患儿脱水纠正时间、大便恢复正常时间明显短于对照组,差异有统计学意义(P<0.05)。治疗组、对照组患儿不良反应发生率分别为9.4%、12.5%,组间差异无统计学意义(P>0.05)。结论:热毒宁注射液用于治疗小儿急性细菌性肠炎,临床疗效好,安全性高。
Objective: To observe the clinical efficacy and safety of Rendunning injection in the treatment of children with acute bacterial enteritis. Methods: 64 children with acute bacterial enteritis were randomly divided into treatment group and control group, 32 cases in each group. The control group was treated with cefixime anti-infective and symptomatic supportive treatment. The treatment group was given heat treatment based on the control group Drug poisoning injection treatment, compared the clinical efficacy of two groups of children after treatment, stool routine examination, clinical symptoms disappeared and the occurrence of adverse drug reactions. Results: The total effective rate was 90.6% in the treatment group, which was significantly higher than that in the control group (68.8%, P <0.05). The normal conversion rate of stool in the 3rd and 5th day after treatment was 65.6% and 96.9% respectively in the treatment group and 56.3% and 75.0% in the control group respectively. There was no significant difference between the two groups in the normal stool conversion rate on the 3rd day P> 0.05). However, the normal rate of stool of the treatment group on the 5th day was significantly higher than that of the control group (P <0.05). The corrected time of dehydration and normal stool recovery were (2.70 ± 0.68) d and (3.02 ± 0.53) d in the treatment group and (4.11 ± 1.02) and 5.08 ± 1.08 days in the control group, respectively. The correction time of dehydration in children in treatment group was significantly shorter than that in control group, with significant difference (P <0.05). The incidence of adverse reactions in the treatment group and control group were 9.4% and 12.5% respectively, with no significant difference between the two groups (P> 0.05). Conclusion: Renduining injection for the treatment of children with acute bacterial enteritis, clinical efficacy, high safety.