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目的探讨CD44Ⅴ6和P27kip1基因蛋白在非小细胞肺癌(NSCLC)组织中的表达及其意义。方法应用免疫组化S-P法检测63例NSCLC组织、20例正常支气管黏膜中CD44Ⅴ6和P27kip1蛋白的表达情况。结果CD44Ⅴ6在NSCLC中的阳性表达率为65·1%,而在正常支气管黏膜中无阳性表达。CD44Ⅴ6的表达与NSCLC的淋巴结转移及TNM分期有关(P<0·01)。P27kip1在正常支气管黏膜和NSCLC组织中的阳性表达率分别为80%和54%,两组比较差异有显著意义(P<0·05)。P27kip1的表达缺失与NSCLC的分化程度、TNM分期以及有无淋巴结转移有关(P<0·05)。结论CD44Ⅴ6和P27kip1基因蛋白在NSCLC的发生、发展、转移过程中均发挥作用,可作为判断NSCLC预后的重要指标。
Objective To investigate the expression and significance of CD44V6 and P27kip1 in non-small cell lung cancer (NSCLC). Methods The expressions of CD44V6 and P27kip1 in 63 NSCLC tissues and 20 normal bronchial mucosa were detected by immunohistochemical S-P method. Results The positive expression rate of CD44Ⅴ6 in NSCLC was 65.1%, but not in normal bronchial mucosa. The expression of CD44V6 was correlated with lymph node metastasis and TNM staging of NSCLC (P <0.01). The positive rates of P27kip1 in normal bronchial mucosa and NSCLC tissues were 80% and 54%, respectively. There was significant difference between the two groups (P <0.05). The loss of P27kip1 expression correlated with the differentiation of NSCLC, TNM stage and lymph node metastasis (P <0.05). Conclusion CD44 6 6 and P27kip1 gene proteins play roles in the development, progression and metastasis of NSCLC, which may be used as an important index to judge the prognosis of NSCLC.