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自体造血干细胞移植 (ASCT)是治疗复发性、难治性和侵袭性恶性淋巴瘤的有效方法 ,但因存在体内肿瘤细胞负荷过多和移植物被肿瘤细胞污染 ,使移植后的复发率增高。为了提高ASCT的疗效 ,可采取 :①移植前美罗华体内净化 ,除去外周血B细胞 ,清除移植物的肿瘤细胞污染 ;②移植后用美罗华和非交叉耐药药物交替联合化疗 ,以杀伤体内肿瘤细胞 ;③移植前或后累及野放射治疗 (IFRT)辅助 ,降低原发灶的复发率
Autologous hematopoietic stem cell transplantation (ASCT) is an effective method for the treatment of recurrent, refractory and invasive malignant lymphomas. However, the recurrence rate after transplantation is increased due to excessive tumor cells in the body and the contamination of tumor cells by the tumor cells. In order to improve the curative effect of ASCT, we can take: (1) Pre-transplant rituximab in vivo purification to remove peripheral blood B cells, clear graft tumor cell contamination; after transplantation with rituximab and non-cross-resistant drug alternating with chemotherapy to kill the tumor cells in vivo ; ③ before or after transplantation involving radiation therapy (IFRT) auxiliary to reduce the recurrence rate of primary