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目的观察尼莫地平联合脑脊液置换治疗蛛网膜下腔出血脑血管痉挛(CVS)的疗效。方法 62例蛛网膜下腔出血患者随机分为治疗组和对照组,各31例。对照组给予常规治疗,治疗组在对照组基础上加用尼莫地平联合脑脊液置换治疗。观察两组疗效和治疗前后大脑中动脉(MCA)血流速度变化。结果治疗组总有效率为90.3%,高于对照组的74.1%,差异有统计学意义(P<0.01);两组治疗后大脑中动脉(MCV)血流速度均明显降低,但治疗组低于对照组,差异均有统计学意义(P<0.01)。结论尼莫地平联合脑脊液置换治疗蛛网膜下腔出血后的疗效显著,可明显降低大脑中动脉(MCV)血流速度。
Objective To observe the curative effect of nimodipine combined with cerebrospinal fluid replacement on cerebral vasospasm (CVS) in patients with subarachnoid hemorrhage. Methods 62 patients with subarachnoid hemorrhage were randomly divided into treatment group and control group, 31 cases in each. The control group was given routine treatment. The treatment group was treated with nimodipine combined with cerebrospinal fluid replacement on the basis of the control group. The curative effect of both groups and the changes of blood flow velocity of middle cerebral artery (MCA) before and after treatment were observed. Results The total effective rate of treatment group was 90.3%, which was higher than that of control group (74.1%), the difference was statistically significant (P <0.01). The blood flow velocity of middle cerebral artery (MCV) In the control group, the differences were statistically significant (P <0.01). Conclusion Nimodipine combined with cerebrospinal fluid replacement for the treatment of subarachnoid hemorrhage was significantly effective, can significantly reduce the middle cerebral artery (MCV) blood flow velocity.