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目的采用气相色谱质谱联用(GC/MS)法检测8种合成大麻素,并对方法进行评价。方法甲醇提取及超声处理样本后,采用GC/MS法检测JWH-203、JWH-250、RCS-4、JWH-018、JWH-019、JWH-122、AM-2201和JWH-210等8种合成大麻素,并对色谱柱、初始温度、升温速率等条件进行了优化。结果使用中等极性的DB-17MS色谱柱(30m×0.32mm×0.25μm),采用起始温度200℃,以20℃/min速率升温至280℃,以10℃/min速率升温至300℃的条件进行检测。8种合成大麻素能够很好的分离,检测限达到20μg/m L;应用该方法对未知样品进行了检测,并对各类合成大麻可能的质谱碎裂途径进行分析。结论本文方法具有分析简便、快速、灵敏的特点,可以用于实际案件的检测。
Objective To detect 8 kinds of synthetic cannabinoids by gas chromatography-mass spectrometry (GC / MS) and evaluate the method. Methods After methanol extraction and sonication, eight compounds including JWH-203, JWH-250, RCS-4, JWH-018, JWH-019, JWH-122, AM-2201 and JWH-210 were detected by GC / Cannabinoids, and the column, the initial temperature, heating rate and other conditions were optimized. Results The medium temperature DB-17MS column (30 m × 0.32 mm × 0.25 μm) was used to raise the temperature to 280 ° C at an initial temperature of 200 ° C and at a rate of 20 ° C / min to 300 ° C at a rate of 10 ° C / min Conditions for testing. Eight synthetic cannabinoids were well separated with a detection limit of 20 μg / mL. Unmeasured samples were detected using this method and possible mass fragmentation pathways for various synthetic cannabis were analyzed. Conclusion This method has the characteristics of simple, rapid and sensitive analysis, which can be used in the detection of actual cases.