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光学拓扑成像方法作为现有脑功能成像模态的有益补充,可以直接同时提供脑组织中氧合血红蛋白(HbO2)和脱氧血红蛋白(Hb)的变化信息,对临床诊断和治疗有重要意义.目前推出的光学拓扑成像系统价格昂贵,难以推广,因此设计了一种结构简单、成本较低的双波长数字锁相光学拓扑成像系统.该系统采用数字锁相检测技术从叠加信号中提取各个分信号的幅值信息,并以修正的Beer-Lambert定律为模型计算每对相邻的源点和探测点之间脑组织的吸收系数变化量.对该拓扑成像系统进行了可行性验证和模拟的实验验证,结果表明,该拓扑成像系统不仅能实现双波长同步测量,还能在一定程度上对目标位置进行有效分辨,并准确反映其吸收系数变化趋势,在大脑皮层各调控区的应激反应过程定性研究中具有重要意义.
Optical topological imaging, as a useful complement to existing brain imaging modalities, can directly and simultaneously provide information about changes of hemoglobin (HbO2) and deoxyhemoglobin (Hb) in brain tissue, which is of great significance for clinical diagnosis and treatment. Optical topological imaging system is expensive and difficult to popularize.Therefore, a simple and low-cost dual-wavelength digital phase locking optical topological imaging system is designed.The digital phase-locked detection technology is used to extract each sub-signal from the superposed signal And the modified Beer-Lambert law is used as a model to calculate the variation of absorption coefficient of brain tissue between each pair of adjacent source and detection points. The feasibility of the topological imaging system and the experimental verification of simulation The results show that this topology imaging system can not only achieve dual-wavelength synchronization measurement, but also effectively resolve the target position to a certain extent and accurately reflect the change trend of its absorption coefficient. The stress response process in each regulatory region of the cerebral cortex qualitatively Research is of great significance.