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循环休克被认为是急性氧自由基过度产生的结果。自旋捕获硝基化合物可通过形成相对稳定的加合物而使自由基失活。本实验的目的在于观察大鼠循环休克的病理生理和进展中N-3-苯-丁基-硝基化合物、α-4-吡啶-氧化物-N-3-丁基-硝基化合物、5-5-二甲基-1-吡咯啉-N-氧化物三种硝基化合物的作用,为前瞻性、随机性、和有对照的实验研究。实验用雄性Wistar大鼠,平均体重200±10克。大鼠循环休克的试验采用三种不同模式:应用大肠杆菌的脂多糖引起致死性内毒素
Circulatory shock is thought to be the result of an over-production of acute oxygen free radicals. Spin capture of nitro compounds can deactivate free radicals by forming relatively stable adducts. The purpose of this experiment is to observe the pathophysiology and progression of rat circulatory shock in N-3-benzene-butyl-nitro compounds, α-4-pyridine-oxide-N-3-butyl-nitro compounds, -5-dimethyl-1-pyrroline-N-oxide three nitro compounds, a prospective, randomized, and controlled experimental study. Experimental male Wistar rats, average body weight 200 ± 10 grams. Three different models of circulatory shock in rats were used: application of lipopolysaccharide from E. coli to lethal endotoxins