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目的观察非酒精性脂肪性肝病(NAFLD)在不同血尿酸(SUA)水平人群中的分布,探讨SUA与NAFLD的相关性。方法选取NAFLD患者(NAFLD组)298例及健康对照者(NC)286名,进一步按SUA水平的四分位数进行分组,比较各组NAFLD的患病率,并进行Logistic回归分析。结果与NC组比较,NAFLD组发病年龄更小,BMI、FPG、SUA、谷丙转氨酶(ALT)、谷草转氨酶(AST)、谷氨酰转肽酶(GGT)、TC、TG、LDL-C、SBP、DBP、胰岛素抵抗指数(HOMA-IR)均升高,仅HDL-C降低,差异有统计学意义(P<0.05)。Logistic回归分析显示,随着SUA水平的升高,发生NAFLD的风险性增大,趋势差异有统计学意义。结论 SUA水平与NAFLD密切相关。
Objective To investigate the distribution of non-alcoholic fatty liver disease (NAFLD) in patients with different levels of serum uric acid (SUA) and to explore the correlation between SUA and NAFLD. Methods A total of 298 NAFLD patients and 286 healthy control subjects were enrolled in this study. The patients were divided into four groups according to the SUA level. The prevalence of NAFLD in each group was compared and analyzed by Logistic regression. Results Compared with NC group, NAFLD group had less age of onset, BMI, FPG, SUA, ALT, AST, GGT, TC, TG, LDL- SBP, DBP, HOMA-IR increased, only HDL-C decreased, the difference was statistically significant (P <0.05). Logistic regression analysis showed that as the level of SUA increased, the risk of NAFLD increased, the trend of difference was statistically significant. Conclusions SUA level is closely related to NAFLD.