在宫颈成熟过程中逐渐发生胶原的解聚和降解。与非妊娠状态相比,成熟宫颈的胶原酶仅轻度增加。Junqueira 等观察到成熟宫颈有明显的中性粒细胞浸润,认为中性粒细胞会释放蛋白酶导致宫颈成熟。Ito 等描述了成熟宫颈含有高浓度的丝氨酸类中性蛋白酶。作者认为粒细胞的弹力蛋白酶对宫颈成熟是一重要因素。本研究报告了有关宫颈组织内弹力蛋白酶的定位,宫颈成熟与宫颈粘液中弹力蛋白酶活性的关系。 In the process of cervical ripening gradually depolymerization and degradation of collagen. Compared with non-pregnant state, the mature cervical collagenase increased only mildly. Junqueira other observed in mature cervical neutrophil infiltration, that neutrophils will release protease leading to cervical ripening. Ito et al. Describe a mature cervix containing a high concentration of serine neutral proteases. The author believes that granulocyte elastase is an important factor for cervical maturation. This study reports on the relationship between cervical tissue elastase localization, cervical maturation and elastase activity in cervical mucus.