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目的:研究依托咪酯用于小儿鼻内镜下腺样体吸割术的麻醉诱导效果,并与丙泊酚作对照方法:60例ASAⅠ～Ⅱ级2～8岁患儿随机分为依托咪酯0.2mg·kg~(-1)组、依托咪酯0.3mg·kg~(-1)组和丙泊酚2mg·kg~(-1)组,每组20例,观察麻醉诱导期血流动力学、麻醉深度的动态变化,以及注射痛、肌阵挛等不良反应。结果:诱导后依托咪酯0.3mg·kg~(-1)组和丙泊酚2mg·kg~(-1)组血压下降较明显,抑制插管后血压反跳较好;依托咪酯0.3mg·kg~(-1)组的心率在整个诱导期间最为平稳;依托咪酯0.3mg·kg~(-1)组脑电双频指投值下降幅度最大,能提供比丙泊酚2mg·kg~(-1)组更深的镇静程度;丙泊酚2mg·kg~(-1)组发生4例(20%)注射痛,依托咪酯0.2mg·kg~(-1)组和依托咪酯0.3mg·kg~(-1)组各发生6例(30%)肌阵挛。结论:0.3mg·kg~(-1)依托咪酯较0.2mg·kg~(-1)依托咪酯更适用于小儿腺样体吸割术的麻醉诱导,能提供和丙泊酚2mg·kg~(-1)相似的效果
Objective: To study the effect of etomidate on anesthesia induced by endoscopic adenoidectomy in children and compare it with that of propofol: 60 ASA Ⅰ ~ Ⅱ grade children aged 2-8 years old were randomly divided into etomid (0.2 mg · kg -1), etomidate 0.3 mg · kg -1 and propofol 2 mg · kg -1 (n = 20 each) were used to observe the blood flow during anesthesia induction Dynamics, depth of anesthesia dynamic changes, and injection pain, myoclonus and other adverse reactions. Results: After induced by etomidate 0.3mg · kg ~ (-1) group and propofol 2mg · kg ~ (-1), the blood pressure drop was more obvious, inhibition of blood pressure rebound after intubation is better; etomidate 0.3mg · The heart rate of kg ~ (-1) group was the most stable during the whole induction period; the decrease of electroencephalogram double-frequency index was the most significant in etomidate 0.3mg · kg ~ (-1) group, which could provide 2mg · kg (-1) group, 4 cases (20%) injected pain in 2mg · kg -1 group of propofol, etomidate 0.2mg · kg -1 group and etomidate 6 cases (30%) myoclonus occurred in 0.3 mg · kg -1 group. CONCLUSION: Etomidone 0.3 mg · kg -1 is more suitable than anesthesia with 0.2 mg · kg -1 etomidate for adenoidectomy in pediatric patients, which can provide propofol 2 mg · kg -1 ~ (-1) similar effect