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本实验应用电镜细胞化学和扫描电镜技术,观察到小白鼠艾氏腹水癌细胞在复方中药注射液的连续作用下,膜表面(Na~+-K~+)-ATP酶活性减弱,微绒毛减退等变化,同时观察到该复方中药注射液对癌细胞增殖的抑制作用,抑瘤率可达87%,癌细胞增殖和(Na~+-K~+)-ATP酶活性及微绒毛的多少有平行关系。讨论了该复方中药抑制癌细胞增殖与膜表面(Na~+-K~+)-ATP酶活性和微绒毛变化的关系。
In this experiment, electron microscopy cytochemistry and scanning electron microscopy techniques were used to observe that Ehrlich ascites carcinoma cells in mice were continuously exposed to compound Chinese herbal injections. The activity of (Na~+-K~+)-ATPase on the membrane surface was weakened and microvilli decreased. Such changes, at the same time observed that the compound Chinese medicine injection inhibition of cancer cell proliferation, tumor inhibition rate of up to 87%, cancer cell proliferation and (Na ~ +-K ~ +) - ATPase activity and the number of microvilli Parallel relationship. The relationship between inhibition of cancer cell proliferation and membrane surface (Na~+-K~+)-ATPase activity and microvilliation was discussed.