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目的了解粘质沙雷菌医院感染的分布特点及对常用抗菌药物的耐药性,为临床抗感染治疗提供依据。方法对四川省科学城医院2010-2013年分离的107株粘质沙雷菌进行细菌的分布和耐药性分析。结果107株粘质沙雷菌主要来自呼吸道(87.9%)。病房分布主要来自老年病房(39.3%)、呼吸内科(17.8%)和重症监护室(15.0%)。耐药率低于10%的抗菌药物有阿米卡星、头孢替坦、头孢吡肟、头孢他啶、哌拉西林/他唑巴坦。2010-2012年间均未检出耐亚胺培南的粘质沙雷菌,2013年对亚胺培南的耐药率增至18.9%。亚胺培南耐药的粘质沙雷菌对抗菌药物耐药率亦明显增高。结论粘质沙雷菌是引起医院感染的常见病原菌,其分离数逐年增加,对常用抗菌药物耐药率呈逐渐增高趋势,临床医生应重视。
Objective To understand the distribution characteristics of Serratia marcescens nosocomial infection and its resistance to commonly used antibiotics to provide the basis for clinical anti-infective therapy. Methods The distribution and drug resistance of 107 strains of Serratia marcescens isolates from 2010-2013 in Sichuan Science City Hospital were analyzed. Results 107 Serratia marcescens mainly came from respiratory tract (87.9%). Ward distribution mainly from the elderly ward (39.3%), Respiratory Medicine (17.8%) and intensive care unit (15.0%). Antimicrobials with less than 10% resistance were amikacin, cefotetan, cefepime, ceftazidime, piperacillin / tazobactam. No imipenem-resistant Serratia marcescens was detected between 2010 and 2012, and the resistance rate to imipenem in 2013 increased to 18.9%. Imipenem-resistant Serratia marcescens also significantly increased resistance to antibiotics. Conclusion Serratia marcescens is a common pathogen causing nosocomial infection. The number of isolates is increasing year by year. The resistance rate to commonly used antimicrobial agents is gradually increasing. Clinicians should pay attention to this.