低雌激素性原发闭经和卵巢早衰25例骨代谢状况观察

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本文采用 GMY-1型骨密度测量仪对10例低雌激素性原发闭经和15例卵巢早衰妇女进行桡骨骨矿含量(BMC)的测定,同时测定血碱性磷酸酶(AKP)和空腹尿钙与肌酐比值(Ca/Cr).发现前者 BMC 的水平低于后者,差异有显著性,且较正常对照组和自然绝经组为低;其空腹尿 Ca/Cr 比值均值的水平显著低于后者,但较正常对照组和自然绝经组为高;血中 AKP 的水平前者高于后者及正常对照组,均有显著性差异.卵巢早衰组 BMC 的水平显著高于自然绝经组,其空腹尿 Ca/Cr 比值均值的水平高于其他各组,均有显著性差异,但血中 AKP 水平均低于其他各组.由此提示:两组患者骨质吸收的速度均大于其相应生成的速度,随着年龄的增加均有过早发生骨质疏松的倾向.故应引起重视并及早予以防治。 In this paper, bone mineral density (BMC) in 10 cases of low estrogen-induced primary amenorrhea and 15 cases of premature ovarian failure were measured by GMY-1 bone mineral density measuring instrument. Meanwhile, AKP and urine fasting urine Calcium and creatinine ratio (Ca / Cr) .BMC levels were lower than the former, the difference was significant, and lower than the normal control group and the natural menopause group; the fasting urine of the average ratio of Ca / Cr was significantly lower than the The latter, but higher than the normal control group and the natural menopause group; the level of blood AKP was higher than the latter and the normal control group, there was a significant difference.The level of BMC in premature ovarian failure group was significantly higher than that of the natural menopause group The mean level of Ca / Cr in fasting urine was significantly higher than that in other groups, but the levels of AKP in blood were lower than those in other groups, suggesting that the rate of bone resorption in both groups was higher than that of other groups Of the speed, with the increase of age tend to have the tendency of osteoporosis, it should pay attention to and early to be controlled.
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