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超抗原作为一种强大的T细胞激活剂,单用极低浓度便可激活大量的T淋巴细胞克隆来杀伤肿瘤细胞,但这种杀伤作用缺乏特异性。靶向治疗是现阶段肿瘤治疗的新技术,可针对各种机制来抑制肿瘤的发生和发展或消除肿瘤。对此,通过单抗导向或将超抗原结合于肿瘤细胞表面以及基因工程等手段,国内外的学者已在超抗原的靶向抗肿瘤治疗方面开展了大量工作,为肿瘤的防治提供了参考依据。
As a powerful T cell activator, superantigens can kill a large number of T lymphocyte clones to kill tumor cells with a very low concentration, but this killing effect is not specific. Targeted therapy is a new technology in cancer therapy at the present stage, which can inhibit the occurrence and development of tumors or eliminate tumors according to various mechanisms. In this regard, through the guidance of monoclonal antibody or superantigen binding to the surface of tumor cells and genetic engineering and other means, scholars at home and abroad have carried out a large number of work on targeted anti-tumor therapy of superantigen, which provides a reference for the prevention and treatment of tumors .