本文报道1例演变为急性髓性白血病的RAEB-t患者只有del(8)(q22)染色体异常,并讨论了该种异常和AML的联系。患者女性,88岁,因充血性心力衰竭和心绞痛入院。既往有冠心病及维生素B_(12)缺乏史。体检,面色苍白,呼吸窘迫,踝部水肿。无脏器和淋巴结肿大。化验:血红蛋白84g/L,血小板数45×10~9/L,白细胞数5.4×10~6/L,其中中性71%,淋巴25%,单核4%。血清总胆红素16μmol/L,结合胆红素8μmol/L(二者正常值分别为3-26和0-5umol/L)。血清铁,总铁结合力、维生素B_(12)、叶酸和结合珠蛋白均在正常范围。大便隐血试验阳性。胃镜检查示良性出血性溃疡。拟诊为胃肠道出血所致的贫血。住院3周后,周围血出现原始细胞和幼稚单核细胞。骨髓原始细胞25%,红系、粒系造血异常,遂 This article reports only one (8) (q22) chromosomal abnormalities in RAEB-t patients that have developed acute myeloid leukemia and discusses the link between this abnormality and AML. Female patient, 88 years old, admitted to hospital with congestive heart failure and angina pectoris. Past history of coronary heart disease and vitamin B_ (12) lack of history. Physical examination, pale, respiratory distress, ankle edema. No organs and swollen lymph nodes. Assay: hemoglobin 84g / L, platelet count 45 × 10 ~ 9 / L, the number of white blood cells 5.4 × 10 ~ 6 / L, of which 71% neutral, lymph 25%, mononuclear 4%. Serum total bilirubin 16μmol / L, combined with bilirubin 8μmol / L (the two normal values ​​were 3-26 and 0-5umol / L). Serum iron, total iron binding, vitamin B_ (12), folic acid and haptoglobin were in the normal range. Occult blood test positive. Gastroscopy showed benign bleeding ulcers. To be diagnosed as gastrointestinal bleeding caused by anemia. Three weeks after hospitalization, there were primitive cells and naive monocytes in peripheral blood. Bone marrow blasts 25%, erythroid, granulocytic abnormalities, then