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目的 探讨扶正化瘀补肾壮骨对老年小鼠骨质疏松的影响。方法 实验用小鼠 60只 ,1 5只 (6月龄 )为青年组 ,另 45只 (2 4月龄 )则随机分为老年组、地塞米松组和中药组。地塞米松组和中药组注射地塞米松 (0 0 0 1 mg g) ,每周 2次 ,共 1 2 w。从第 1 3周至第 2 0周停止注射地塞米松。中药组给予口服中药。于第 2 0周末 ,处死所有动物 ,测量股骨体积 ,整骨钙量 ,计算单位体积钙含量。结果 青年组钙含量 (0 360 6± 0 0 4 3 1 g cm3 )高于老年组 (0 2 2 1 5± 0 0 2 6 3 g cm3 ) (P<0 0 1 )。中药组 (0 1 878± 0 0 1 95 g cm3 )高于地塞米松组 (0 1 689± 0 0 2 3 0 g cm3 ) (P<0 0 5) ,但低于老年组 (P<0 0 1 )。结论 扶正化瘀补肾壮骨可有效治疗老年性骨质疏松。
Objective To explore the effect of Fuzheng Huayu Bushen Zhuanggu on osteoporosis in aged mice. Methods A total of 60 mice were used in the experiment, 15 (6 months old) were young, and 45 (24 months) were randomly divided into old group, dexamethasone group and traditional Chinese medicine group. Dexamethasone (0.10 mg g) was injected into the dexamethasone group and the Chinese medicine group twice a week for a total of 12 w. Dexamethasone was stopped from the 1st week to the 20th week. The Chinese medicine group gave oral Chinese medicine. At the end of the 20th week, all animals were sacrificed, femur volume was measured, bone calcium was calculated, and calcium content per unit volume was calculated. Results The calcium content in the young group was higher than that in the old group (0 360 6± 0 0 4 3 1 g cm3) (0 2 2 1 5± 0 0 2 6 3 g cm3) (P < 0 01). The Chinese medicine group (0 1 878 ± 0 0 1 95 g cm3) was higher than the dexamethasone group (0 1 689 ± 0 0 2 3 0 g cm3) (P < 0 05), but lower than the old group (P <0 0 1 ). Conclusion Fuzheng Huayu Bushen Zhuanggu can effectively treat senile osteoporosis.