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目的探讨音乐联合奥氮平治疗对儿童少年期精神分裂症患儿认知功能的影响,及事件相关电位P300对其疗效的评价作用。方法选取儿童少年期精神分裂症患儿60例,随机分成2组。单用奥氮平治疗组(奥氮平组)和奥氮平联合音乐治疗组(联合组),同时选取健康儿童少年30例作为健康对照组。比较治疗前后3组儿童事件相关电位P300 N1、P2、N2、P3潜伏期、波幅及反应时间的差异。结果与健康对照组比较,治疗前奥氮平组P2、N2、P3潜伏期及反应时间明显延长(P<0.05,0.01),P2、N2、P3波幅明显降低(P<0.05,0.01);联合组P2、N2、P3潜伏期及反应时间明显延长(P<0.05,0.01)。治疗后奥氮平组P2、P3潜伏期及反应时间明显长于联合组(P<0.05,0.01),P2、P3波幅明显低于联合组(P<0.05)。结论音乐治疗对儿童少年期精神分裂症患儿认知功能的改善有辅助治疗作用,事件相关电位可评估患儿认识功能损害情况。
Objective To investigate the effect of music combined with olanzapine on cognitive function in children with schizophrenia in adolescence and to evaluate the effect of event-related potential P300 on its efficacy. Methods Sixty children with schizophrenia in children and adolescents were randomly divided into two groups. Only olanzapine treatment group (olanzapine group) and olanzapine combined music therapy group (combination group), while 30 healthy children and adolescents were selected as healthy control group. The differences of latency, amplitude and reaction time of P300 N1, P2, N2, P3 in three groups before and after treatment were compared. Results Compared with the healthy control group, the latency and reaction time of P2, N2 and P3 in the pre-treatment olanzapine group were significantly prolonged (P <0.05 and 0.01), while the amplitude of P2, N2 and P3 was significantly decreased (P <0.05 and 0.01) P2, N2, P3 latency and reaction time was significantly longer (P <0.05,0.01). After treatment, the latency and reaction time of P2, P3 in olanzapine group were significantly longer than those in the combined group (P <0.05, 0.01). The amplitude of P2 and P3 in the olanzapine group was significantly lower than that in the combined group (P <0.05). Conclusion Music therapy can improve cognitive function in children with adolescent schizophrenia. It can be used to evaluate the cognitive impairment in children.