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目的分析探讨老年患者冠脉狭窄严重度与血清25(OH)D3水平的关系。方法选取277例老年患者,测量患者体内25(OH)D3水平,根据患者的25(OH)D3水平分为Q1组(<15.0nmol/L,62例),Q2组(15.0~22.1nmol/L,76例),Q3组(22.2~35.6nmol/L,70例)和Q4组(>35.6nmol/L,69例)。运用Logistic回归分析25(OH)D3水平和患者发生冠状动脉狭窄的关系。结果 Q1、Q2、Q3 3组患者的尿酸、他汀类药物和CRP水平及阿司匹林用药情况等均与Q4组患者比较差异有统计学意义(P<0.05);冠脉狭窄度评分Q1组患者和Q3组、Q4组患者的比较差异有统计学意义(P<0.05),Q2组患者和Q3组、Q4组患者的比较差异有统计学意义(P<0.05)。结论患者体内25(OH)D3水平低下和患者冠状动脉狭窄有关。
Objective To investigate the relationship between the severity of coronary artery stenosis and serum 25 (OH) D3 in elderly patients. Methods A total of 277 elderly patients were enrolled in this study. The 25 (OH) D3 levels in patients were measured. The levels of 25 (OH) D3 were divided into Q1 group (<15.0 nmol / L, 62 cases) , 76 cases), Q3 group (22.2 ~ 35.6nmol / L, 70 cases) and Q4 group (> 35.6nmol / L, 69 cases). The relationship between 25 (OH) D3 level and coronary artery stenosis was analyzed by Logistic regression. Results The levels of uric acid, statins, CRP and aspirin in Q1, Q2 and Q3 groups were significantly different from those in Q4 group (P <0.05). The scores of coronary artery stenosis in Q1 group and Q3 There was significant difference between the Q4 group and the Q4 group (P <0.05). The difference between the Q2 group and the Q3 group and the Q4 group was statistically significant (P <0.05). Conclusions The low level of 25 (OH) D3 in patients is associated with coronary stenosis.