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目的观察青蒿琥酯对大鼠斯氏狸殖吸虫感染的治疗效果。方法用斯氏狸殖吸虫囊蚴腹腔内注射感染大鼠,感染30d后用不同疗程和剂量给予治疗。治疗结束后30d剖杀所有大鼠,收集虫体。同时设吡喹酮治疗组和对照组。结果青蒿琥酯每周1次给药连服4次,50mg/kg、100mg/kg、150mg/kg组、吡喹酮治疗组、对照组的检虫率分别为35.5%、37.0%、37.5%、19.5%和40.5%。青蒿琥酯50mg/kg.7d组、100mg/kg.7d组、150mg/kg.7d组、吡喹酮治疗组、对照组的检虫率分别为26.0%、23.3%、70.0%、22.7%、83.3%。结论青蒿琥酯对大鼠体内的斯氏狸殖吸虫有较好的杀虫效果。
Objective To observe the therapeutic effect of artesunate on the infection of S. coimici in rats. Methods Infected with intraperitoneal injection of Campylobacter serogroup Campylobacter infected rats, 30d after infection with different courses and doses of treatment. 30d after treatment, all rats were killed and the parasites were collected. Praziquantel treatment group and control group. Results Artesunate was administered once a week for 4 times. The rates of sepsis in the 50 mg / kg, 100 mg / kg, 150 mg / kg and praziquantel groups were 35.5%, 37.0% and 37.5 %, 19.5% and 40.5%. Artemether 50mg / kg.7d group, 100mg / kg.7d group, 150mg / kg.7d group, praziquantel treatment group, the control group were 26.0%, 23.3%, 70.0%, 22.7% , 83.3%. Conclusion Artesunate has a good insecticidal effect on S. copepods in rats.