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目的探讨微波联合重组人干扰素α-2b喷雾剂局部外用与单用微波治疗、微波联合重组人干扰素α-2b注射液肌内注射3种方法治疗尖锐湿疣的不良反应、复发情况及临床疗效。方法选择2015年1月至9月邯郸市第一医院就治的150例尖锐湿疣患者,其中男性78例,女性72例;年龄13~56岁,平均年龄27.12岁。随机分为A、B、C组,每组各50例。A组单用微波治疗;B组在A组治疗基础上,用重组人干扰素α-2b注射液300 IU肌内注射,隔日1次,治疗7次为一个疗程,共2个疗程;C组在A组治疗基础上,外用重组人干扰素α-2b喷雾剂均匀喷涂于创面,每处1~2喷,每天4次,连续4周。3组患者均在治疗结束后每个月复诊,连续随访6个月,分别记录治疗后1、2、3、6个月不良反应、复发情况并判断临床疗效。结果 A组有效率40%,B组72%,C组70%;A组与B组比较,差异有统计学意义(χ~2=10.390,P<0.05);A组与C组比较,差异有统计学意义(χ~2=9.091,P<0.05);B组与C组比较,差异无统计学意义(χ~2=0.049,P>0.05)。治疗后3组患者复发情况比较:A组42例,B组31例,C组33例;治疗后第1个月B组与C组差异无统计学意义(χ~2=0.038,P>0.05),C组与A组比较,结果显示C组复发率较A组明显下降,差异显著,有统计学意义(χ~2=14.440,P<0.05);随访6个月,总复发率,B、C两组情况相当,差异无统计学意义(χ~2=0.045,P>0.05),C组与A组差异有统计学意义(χ~2=7.013,P<0.05)。结论微波治疗联合外用重组人干扰素α-2b喷雾剂治疗尖锐湿疣临床效果高,复发率低,值得临床推广应用。
Objective To investigate the adverse reactions, recurrences and clinical effects of microwave combined with rhIFNα-2b topical application and microwave therapy alone and microwave combined with recombinant human interferon α-2b injection intramuscularly for the treatment of condyloma acuminatum . Methods A total of 150 cases of condylomata acuminatum were treated in Handan No.1 Hospital from January to September 2015, including 78 males and 72 females, aged from 13 to 56 years (mean age, 27.12 years). Randomly divided into A, B, C group, each group of 50 cases. Group A was treated with microwave only; Group B was intramuscularly injected with 300 IU of recombinant human interferon alpha-2b on the basis of group A, once every other day for 7 times for one course for a total of 2 courses; Group C On the basis of group A treatment, external application of recombinant human interferon α-2b spray evenly sprayed on the wound, each 1 to 2 spray, 4 times a day for 4 weeks. All patients in the three groups were followed up every month for 6 months. The adverse reactions and recurrences were recorded at 1, 2, 3 and 6 months after treatment, and the clinical efficacy was evaluated. Results The effective rate was 40% in group A, 72% in group B and 70% in group C. The difference between group A and group B was statistically significant (χ ~ 2 = 10.390, P <0.05) (Χ ~ 2 = 9.091, P <0.05). There was no significant difference between group B and group C (χ ~ 2 = 0.049, P> 0.05). There was no significant difference between group B and group C at the first month after treatment (χ ~ 2 = 0.038, P> 0.05). There was no significant difference in the relapse between the three groups after treatment: 42 cases in group A, 31 cases in group B and 33 cases in group C ), C group and A group, the results showed that the recurrence rate of C group was significantly lower than that of A group, the difference was statistically significant (χ ~ 2 = 14.440, P <0.05); followed up for 6 months, the total recurrence rate, B There was no significant difference between the two groups (χ ~ 2 = 0.045, P> 0.05). The difference between C group and A group was statistically significant (χ ~ 2 = 7.013, P <0.05). Conclusion The combination of microwave therapy and external use of recombinant human interferon α-2b spray for the treatment of condyloma acuminatum has high clinical efficacy and low recurrence rate, which is worthy of clinical application.