Ａｌｐｏｒｔ综合征的诊断依据包括血尿性肾病 ,肾功能不全、神经性耳聋、肾脏或眼疾患家族史 ,同时电镜显示肾小球基底膜增厚伴致密层分离 ,破碎。大量蛋白尿往往表示预后不良 ,最终发展为肾功能衰竭。 1 991年作者报道了 8例Ａｌｐｏｒｔ综合征患者应用环孢素Ａ(ＣｓＡ)治疗 The diagnosis of Alport syndrome includes hematuria, renal insufficiency, neurological deafness, family history of kidney or eye disease, and electron microscopy shows glomerular basement membrane thickening with dense layer separation and broken. Large amounts of proteinuria often indicate a poor prognosis, ultimately developing renal failure. In 1991, the authors reported the use of cyclosporin A (CsA) in 8 patients with Alport’s syndrome