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目的探讨联合雾化吸入布地奈德混悬液与γ-干扰素预防急性上呼吸道感染(AURI)诱发婴幼儿喘息性疾病的疗效。方法将2008年1-12月在武汉市妇女儿童医疗保健中心儿科门诊治疗的既往有毛细支气管炎病史的AURI患儿150例作为研究对象。男87例,女63例;年龄2个月～3岁。按就诊顺序分为治疗组和对照组,每组各75例。对照组予常规综合治疗;治疗组患儿在此基础上,采用空气压缩泵联合雾化吸入布地奈德混悬液(每次0.5 mg)与γ-干扰素(每次0.5×105IU),加入9 g.L-1盐水2 mL稀释雾化吸入,2次.d-1,疗程5～7 d。统计二组自发生AURI起14 d内发生毛细支气管炎、喘息性支气管炎和哮喘病例数,对二组出现喘憋、肺部哮鸣音及阻塞性肺气肿情况和发生喘息性疾病情况进行比较。结果治疗组喘憋、肺部哮鸣音及胸片示阻塞性肺气肿发生率均明显低于对照组(χ2=13.79、54.15、29.40,Pa<0.01)。治疗组喘息性疾病发生率明显低于对照组(χ2=13.79,P<0.01)。结论联合雾化吸入布地奈德混悬液与γ-干扰素预防AURI诱发婴幼儿喘息性疾病疗效确切,方法简便,不良反应小。
Objective To investigate the efficacy of combined inhalation of budesonide suspension and interferon-gamma in the prevention of wheezing-induced diseases in infants with acute upper respiratory tract infection (AURI). Methods A total of 150 children with AURI who had a history of bronchiolitis underwent pediatric outpatient treatment in Wuhan Women and Children’s Medical Center from January to December in 2008. 87 males and 63 females; aged 2 months to 3 years old. According to the order of treatment was divided into treatment group and control group, 75 cases in each group. On the basis of this, the patients in the treatment group were treated with inhalation of budesonide suspension (0.5 mg each time) and interferon-γ (0.5 × 105 IU each time) Dilution of 9 gL-1 saline 2 mL inhalation, 2 times .d-1, treatment of 5 ~ 7 d. The number of cases of bronchiolitis, asthmatic bronchitis and asthma occurred within 14 days after the onset of AURI in the two groups were observed. The wheezing, wheezing and obstructive pulmonary emphysema in the two groups and wheezing diseases were observed Compare Results The incidences of wheezing, wheezing in the lungs and obstructive pulmonary emphysema in the chest radiographs in the treatment group were significantly lower than those in the control group (χ2 = 13.79, 54.15, 29.40, Pa0.01). The incidence of asthmatic disease in the treatment group was significantly lower than that in the control group (χ2 = 13.79, P <0.01). Conclusions The combined inhalation of budesonide suspension with interferon-gamma in the prevention of wheezing-induced diseases induced by AURI is effective, simple and convenient, and has a small adverse reaction.