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遗传过敏性皮炎(AD)是严重的湿疹性皮肤病,其发生有遗传背景并与变应性哮喘、鼻炎等有关,属IgE介导的I型变态反应,其末梢血中IgE升高,CD4~+T细胞不平衡。近年来,已知IgE合成调节的过程中,直接牵涉到B细胞、T细胞、白细胞介素4(IL-4),γ-干扰素(γ-IFN)之间的相互作用,IL-4可诱导B细胞产生IgE;活化了的T细胞可产生γ-IFN,它能抑制IgE合成,根据其对IgE的下调作用,特别有趣的是γ-IFN由外周CD4~+T细胞的一种特殊亚
Allergic atopic dermatitis (AD) is a severe eczematous dermatosis that has a genetic background and is associated with allergic asthma, rhinitis, etc. It is an IgE-mediated type I allergic reaction with increased IgE in peripheral blood and CD4 ~ + T cell imbalance. In recent years, the regulation of IgE synthesis is known to directly involve the interaction between B cells, T cells, Interleukin 4 (IL-4) and Interferon-gamma (IFN-γ) Induction of B cells to produce IgE; activated T cells produce gamma-IFN, which inhibits IgE synthesis and is of particular interest according to its downregulation of IgE, which is of particular interest from peripheral CD4 ~ + T cells