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目的了解解脲脲原体(Uu)和人型支原体(Mh)感染状况及耐药性变化,为临床合理使用抗生素提供科学依据。方法采用支原体培养鉴定及药敏试剂盒,对660例女性宫颈分泌物进行培养鉴定及药敏试验。结果支原体感染阳性508例(阳性率76.9%),其中Uu单纯感染374例(阳性率56.7%);Mh单纯感染4例(阳性率0.6%);Uu和Mh混合感染130例(阳性率20%)。药敏结果显示,美满霉素、强力霉素、交沙霉素对两种支原体敏感性最高,Uu分别为90%、87.2%、80.2%;Uu+Mh分别为78.5%、75.4%、70.8%;4例单纯Mh阳性者对罗红霉素与阿奇霉素全部耐药,对美满霉素、强力霉素无一例耐药。结论美满霉素、强力霉素、交沙霉素作为目前治疗生殖道感染的首选药物,临床诊治前应尽可能进行支原体培养及药敏试验,以合理规范用药。
Objective To understand the infection status and drug resistance changes of Uu and Mh and provide a scientific basis for rational use of antibiotics in clinic. Methods Mycoplasma culture identification and drug sensitivity kit, 660 cases of female cervical secretions culture identification and drug sensitivity test. Results Mycoplasma infection was positive in 508 cases (positive rate was 76.9%), of which 374 cases were Uu infection (positive rate was 56.7%), 4 cases were Mh infection (positive rate was 0.6%), 130 cases were Uu and Mh mixed infection (positive rate was 20% ). Susceptibility of minocycline, doxycycline and jasamycin were the highest, Uu were 90%, 87.2%, 80.2% respectively; Uu + Mh were 78.5%, 75.4%, 70.8% ; 4 cases of Mh-positive were all resistant to roxithromycin and azithromycin, no resistance to minocycline and doxycycline. Conclusion Minocycline, doxycycline, josamycin as the first choice of treatment of genital tract infections, clinical diagnosis and treatment of mycoplasma should be carried out as far as possible and susceptibility testing to rationalize the use of drugs.