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最近研究表明,重组卡介苗(rBCG)可集载体与佐剂的功能于一身,同时具备接种一次就可以获得强而持久特异性免疫的特点。因此BCG是研制新型重组活疫苗的一种理想的载体。本文简要概述了近年来构建的rBCG疫苗及其载体在细菌、病毒等微生物和寄生虫等感染性疾病中的应用和意义。
Recent studies have shown that recombinant BCG (rBCG) can be a combination of the vector and adjuvant functions, with the strong and long-lasting specific immunity can be obtained once inoculated. BCG is therefore an ideal vehicle for the development of new recombinant live vaccines. This article briefly outlines the application and significance of the rBCG vaccine and its vector constructed in recent years in infectious diseases such as bacteria, viruses and other microorganisms and parasites.