Reductive cleavage of the N-O bond of isoxazolidine ring with catalytic hydrogenation over Raney nickel was described.Bicyclic isoxazolidines could be effectively converted into the corresponding 1,3-amino-alcohol possessing a sultone or sultam moiety with high conversion and yield when the hydrogenation was catalyzed by freshly prepared Raney nickel under a pressure of 40 psi in the presence of triethylamine.