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目的 研究幽门螺杆菌 L 型 (H p- L 型 )和 HPV16、18感染与人食管癌的关系 ,探讨 H p- L 型致癌机制。方法 应用革兰染色和免疫组化染色技术 ,对 112例食管鳞癌和 30例对照组进行 H p- L型和 HPV16、18同步检测。结果 革兰染色 L型检出率 (6 7.9% )与对照组 (2 6 .7% )有显著性差异 (P<0 .0 5 ) ;与免疫组化 H p- L型抗原检出阳性率 (6 5 .2 % )无显著性差异(P>0 .0 5 )。H p- L型检出阳性率为 6 1.6 % (6 9/ 112 )。HPV 16、18表达阳性率为 6 9.6 % ,与 H p- L型检出阳性率无显著性差异(P>0 .0 5 ) ;H p- L 型和 HPV16、18同时阳性者占 5 9.8% (6 7/ 112 )结论 H p- L 型和 HPV16、18感染与食管癌发生相关。H p- L型感染可能是食管癌除病毒之外的又一生物性致癌因素
Objective To investigate the relationship between Helicobacter pylori L-type (H p-L type) and HPV16, 18 infections and human esophageal cancer and explore the mechanism of H p-L carcinogenesis. Methods Gram-negative and immunohistochemical staining techniques were used to detect H p L type and HPV 16 and 18 simultaneously in 112 cases of esophageal squamous cell carcinoma and 30 controls. Results The detection rate of Gram-stained L-form (6 7.9%) was significantly different from that of the control group (26.7%) (P<0.05); positive with the immunohistochemical H p-L antigen detection The rate (65.2%) was not significantly different (P>0.05). The positive rate of H p-L was 61.6% (6 9/ 112). The positive rate of HPV 16 and 18 was 6 9.6 %, which was not significantly different from that of H p L type (P>0.05). The positive rate of H p L type and HPV 16 and 18 was 59.8. % (67/112) Conclusions H p-L and HPV 16 and 18 infections are associated with the development of esophageal cancer. H p-L infection may be another biological carcinogenic factor besides virus in esophageal cancer