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目的观察红花黄色素氯化钠注射液辅助治疗高原地区慢性肺心病急性加重期患者的疗效。方法 80例肺心病患者随机分为对照组40例,男性26例,女性14例,年龄(66±7)岁,给予常规治疗;治疗组40例,男性28例,女性12例,年龄(67±7)岁,在常规治疗基础上,给予红花黄色素氯化钠注射液80 mg静脉滴注,1次·d~(-1),共14d;观察2组治疗效果、治疗前后临床症状缓解情况、血气分析及肺动脉压力的变化。结果治疗组的总有效率为88%,显著高于对照组(68%)(P<0.05);治疗组的二氧化碳分压下降了(27±15) mmHg、氧分压升高了(25±10) mmHg,均优于对照组,心率、呼吸频率的改善较对照组更佳,其差异均有显著意义(P<0.05,P<0.01);治疗组肺动脉收缩压降低(36±18) mmHg、肺动脉平均压降低(30±15) mmHg,均优于对照组(P<0.01);治疗组1例患者出现轻微头痛。结论红花黄色素氯化钠注射液可改善慢性肺源性心脏病患者急性加重期临床症状,同时能降低肺动脉压力,使用安全有效。
Objective To observe the curative effect of safflower yellow and sodium chloride injection on patients with acute exacerbation of chronic pulmonary heart disease in the plateau area. Methods Eighty patients with cor pulmonale were randomly divided into control group (n = 40), male 26, female 14 (66 ± 7) years old, and received routine treatment. The treatment group included 40 cases, 28 males and 12 females, ± 7) years of age, on the basis of routine treatment, given safflower yellow sodium chloride injection 80 mg intravenously, 1 d · (-1), a total of 14 days; observed two groups of treatment, clinical symptoms before and after treatment Mitigation, blood gas analysis and changes in pulmonary artery pressure. Results The total effective rate in the treatment group was 88%, significantly higher than that in the control group (68%) (P <0.05). The partial pressure of carbon dioxide in the treatment group decreased by (27 ± 15) mmHg and the oxygen partial pressure increased by (P <0.05, P <0.01). The systolic pressure of pulmonary artery in treatment group was lower than that of control group (36 ± 18) mmHg , Mean pulmonary artery pressure (30 ± 15) mmHg, were better than the control group (P <0.01); 1 patient in the treatment group had mild headache. Conclusion Safflower yellow sodium chloride injection can improve clinical symptoms of acute exacerbation of patients with chronic cor pulmonale, reduce pulmonary artery pressure, and be safe and effective.