论文部分内容阅读
Protein kinases C(PKCs),a big family including 12isoenzymes,are divided into three major groupsaccording to the variability of their regulatory domains.The classical PKCs(cPKC)including PKC_α,PKC_(β1),PKC_(β2),and PKC_γ need calcium,phosphatidylserine,anddiacylglycerol or phorbol esters for full activation.Thenovel PKCs(nPKC)including PKC_δ,PKC_ε,PKC_η,PKC_θ,and PKC_μ do not require calcium for their activation.Thethird group is the atypical PKCs(aPKC)including PKC_ζ,PKC_λ,and PKC_ι whose activation depends on
Protein kinases C (PKCs), a big family including 12isoenzymes, are divided into three major groups according to the variability of their regulatory domains. The classical PKCs (cPKC) including PKC_α, PKC_ (β1), PKC_ (β2), and PKC_γ need calcium , phosphatidylserine, and diacylglycerol or phorbol esters for full activation. Shenovel PKCs (nPKC) including PKC_δ, PKC_ε, PKC_η, PKC_θ, and PKC_μ do not require calcium for their activation. These tertiary groups are the atypical PKCs (aPKC) including PKC_ζ, and PKC_ι whose activation depends on