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目的:收集植物性雌激素异黄酮与乳腺癌发病风险的文献,并对文献进行统计学Meta分析,探讨植物性雌激素异黄酮与乳腺癌的相关性。方法:以“异黄酮、大豆和乳腺肿瘤”等为关键词,检索CHKD期刊全文数据库、中国生物医学文献数据库(CBM)和medline,收集2001-2011年发表的植物性雌激素异黄酮与乳腺癌发病风险的文献。应用统计学软件对文献数据进行统计分析。结果:共7项研究被纳入分析。7项研究存在异质性(Q=1.84,P=0.000),采用随机效应模型进行合并计算,豆制品的合并RR值为0.73,95%CI=0.58～0.94。对分析结果进行偏倚分析显示,漏斗图中各研究因素分布基本对称,无发表偏倚。结论:对这7项研究数据分析后显示,植物性雌激素异黄酮可能是乳腺癌的保护性因素,异黄酮的摄入可以降低乳腺癌发病风险。
OBJECTIVE: To collect literature on the risk of phytoestrogen isoflavones and breast cancer, and to make a statistical meta-analysis on the literature to explore the relationship between phytoestrogen isoflavones and breast cancer. METHODS: The key words of “Isoflavones, Soybean and Breast Tumors” were searched for CHKD full-text database, CBM and medline, and the phytoestrogen isoflavones Literature on the risk of breast cancer. Statistical analysis of literature data is made using statistical software. Results: A total of seven studies were included in the analysis. Seven studies were heterogeneous (Q = 1.84, P = 0.000). The combined effect of random effects model was calculated. The combined RR of soybean products was 0.73, and the 95% CI was 0.58 ~ 0.94. The bias analysis of the analysis results shows that the distribution of each research factor in the funnel diagram is basically symmetrical and there is no publication bias. Conclusion: The analysis of these 7 studies shows that phytoestrogen isoflavones may be a protective factor in breast cancer. Ingestion of isoflavones can reduce the risk of breast cancer.