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目的:研究斑蝥黄微胶囊在家兔体内的药代动力学。方法:家兔单剂量灌胃给予斑蝥黄微胶囊后,在不同时间点经后肢静脉采血,用LC-MS法测定血浆中斑蝥黄质量浓度。药代动力学参数运用DAS2.1软件处理。结果:家兔灌胃给予斑蝥黄微胶囊后斑蝥黄浓度-时间曲线符合二室模型,主要药代动学参数Tmax=300 min,Cmax=(75.761±0.739)μg·L-1,t1/2z=(527.408±208.401)min,AUC(0-t)=(23 057.221±1 582.299)μg·L-1·min-1,Vz/F=(1 569.453±258.575)L·kg-1。结论:家兔灌胃给予斑蝥黄微胶囊后,斑蝥黄在体内消化吸收缓慢、体内分布广泛,说明斑蝥黄微胶囊具有稳定和缓释的特点。
Objective: To study the pharmacokinetics of Canthaxanthin microcapsule in rabbits. Methods: Rabbits were given intragastric administration of canthaxanthin microcapsule by intragastric administration, blood was collected from hindlimb vein at different time points, and the plasma concentration of canthaxanthin was determined by LC-MS. Pharmacokinetic parameters using DAS2.1 software. Results: The concentration-time curve of spotted yellow in rabbits administered gavage Huang capsule could meet the two-compartment model. The main pharmacokinetic parameters were Tmax = 300 min, Cmax = (75.761 ± 0.739) μg · L-1, t1 / 2z = (527.408 ± 208.401) min, AUC (0-t) = (23 057.221 ± 1 582.299) μg · L-1 · min-1, Vz / F = (1 569.453 ± 258.575) L · kg -1. CONCLUSION: After intragastric administration of Canthaxanthin microcapsules, the absorption and absorption of canthaxanthin in the body are slow and the body is widely distributed, which shows that the canthaxanthin microcapsules have the characteristics of stable and sustained release.