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目的:观察子宫内膜异位症患者根治手术后应用激素替代治疗的临床疗效及其安全性。方法:选择自2010年1月～2011年1月收治的43例子宫内膜异位症根治术后患者,将患者分为对照组21例与治疗组22例,治疗组患者每日1次口服戊酸雌二醇0.5～1.0 mg;对照组患者每日或隔日1次口服利维爱1.25 mg。检查两组患者盆腔情况,体内血清促卵泡素(FSH)、血清雌二醇(E2)水平,有无不良反应等。结果:患者经过9个月的治疗及观察后,无明显异常及不良症状出现,绝经期症状得到有效缓解,体内血清E2水平及K评分与治疗前有明显改善,差异对比具有统计学意义(P<0.05)。结论:小剂量应用雌激素替代治疗对于改善子宫内膜异位症根治术后绝经症状具有较好的改善效果,使用戊酸雌二醇替代治疗相对安全。
Objective: To observe the clinical efficacy and safety of hormone replacement therapy in patients with endometriosis after radical surgery. Methods: Forty-three patients with endometriosis who underwent radical surgery from January 2010 to January 2011 were divided into control group (n = 21) and treatment group (n = 22). Patients in the treatment group were treated orally once daily Estradiol valerate 0.5 ~ 1.0 mg; control group patients with oral Levi 1.25 mg once daily or every other day. Check the pelvic conditions in both groups, in vivo serum follicle stimulating hormone (FSH), serum estradiol (E2) levels, with or without adverse reactions. Results: After 9 months of treatment and observation, no obvious abnormalities and adverse symptoms were found in the patients. The menopausal symptoms were effectively relieved. The levels of serum E2 and K in the serum were significantly improved as compared with those before treatment, and the difference was statistically significant (P <0.05). Conclusion: The low dose of estrogen replacement therapy can improve the menopausal symptoms after endometriosis. The estradiol valerate replacement therapy is relatively safe.